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Functional Assessment of Cancer Therapy – Anemia

For patients with Anemia/Fatigue



Below are the details for the FACT-An measure:


Functional Assessment of Cancer Therapy – Anemia (FACT-An)






Cancer patients 18 years and older with anemia


Past 7 days


5 point Likert-type scale


Paper and electronic


Self-administration and interview when applicable


Physical Well-Being, Social/Family Well-Being, Emotional Well-Being, Functional Well-Being, Anemia Subscale


10-15 minutes


Manual scoring template, some items are reverse scored. Subscale scores, total scores and TOI scores possible. SAS/SPSS algorithms available.


FACIT-Fatigue, FACIT-F, PROMIS SF v1.0 – Fatigue 13a

Language Availability

Available translations of the FACT-An can be obtained by registering for permission. Users are not permitted to translate the FACT-An without permission from Permission from to translate the FACT-An may also be contingent upon timeline expectations and availability of FACIT staff. Translations must undergo a rigorous methodology under the guidance of which includes multiple translators, QA steps and cognitive interviews with patients. For commercial use, FACITtrans is the approved translation vendor to translate the FACIT measurement system.

Please contact us for more information.

Language Availability


Licensing fees are assessed on a per trial/per measure basis for commercial use. There is no fee for use of the English version, but a license should be obtained.

Non-commercial use is assessed on a case-by-case basis. Licensing fees are typically not applied to investigator-initiated research, students, or clinical use.

To license an available version of this measure for commercial or non-commercial use, please complete our registration form. All of the information provided in the form will be kept strictly confidential. For questions, please contact us.

Selected References

Selected References

Casadevall, N., Durieux, P., Dubois, S., Hemery, F., Lepage, E., Quarré, M., Damaj, G., Giraudier, S., Guerci, A., Laurent, G., Dombret, H., Chomienne, C., Ribrag, V., Stamatoullas, A., Marie, J., Vekhoff, A., Maloisel, F., Navarro, R., Dreyfus, F., & Fenaux, P.  Health, economic, and quality-of-life effects of erythropoietin and granulocyte colony-stimulating factor for the treatment of myelodysplastic syndromes: a randomized, controlled trial.  Blood 2004; 104(2): 321-327.  doi: 10.1182/blood-2003-07-2252.

Greenberg, P., Sun, Z., Miller, K., Bennett, J., Tallman, M., Dewald, G., van der Jagt, R., Houston, J., Thomas, M., Cella, D., & Rowe, J.  Treatment of myelodysplastic syndromes patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase III trial  by the Eastern Cooperative Oncology Group (E1996). Blood 2009; 114(12): 2393–2400. doi: 10.1182/blood-2009-03-211797. 

Mesa, R., Niblack, J., Wadleigh, M., Verstovsek, S., Camoriano, J., Barnes, S., Tan, A., Atherton, P., Sloan, J., Tefferi, A.  The Burden of Fatigue and Quality of Life in Myeloproliferative Disorders (MPDs).  An International Internet-Based Survey of 1179 MPD Patients.  Cancer 2007; 109(1): 68-76.  doi: 10.1002/cncr.22365.

Pinchon, D., Stanworth, S., Dore ´e, C., Brunskill, S., & Norfolk, D.  Quality of life and use of red cell transfusion in patients with myelodysplastic syndromes. A systematic review.  American Journal of Hematology 2009; 84(10):671-677.  doi: 10.1002/ajh.21503.

Spiriti. M., Latagliata, R., Niscola, P., Cortelezzi. A., Francesconi. M., Ferrari, D., Volpe, E., Clavio, M., Grossi. A., Reyes, M., Musto, P., Mitra, M., Azzarà, A., Pagnini, D., D’Arena, G., Spadano, A., Balleari, E., Pecorari, P., Capochiani, E., De Biasi, E., Perego, D., Monarca, B., Pisani, F., Scaramella, G., & Petti, M. Impact of a new dosing regimen of epoetin alfa on quality of life and anemia in patients with low-risk myelodysplastic syndrome.   Ann Hematol 2005; 84: 167–176.  doi: 10.1007/s00277-004-0961-9.

Steensma, D., Heptinstall, K., Johnson, V., Novotny, P., Sloan, J., Camoriano, J., Niblack, J., Bennett, J., & Mesa, R.  Common troublesome symptoms and their impact on quality of life in patients with myelodysplastic syndromes (MDS): Results of a large internet-based survey.  Leukemia Research 2008; 32: 691-698.  doi: 10.1016/j.leukres.2007.10.015.

Trudeau, J.J., He, J., Rose, E. et al. Content validity of patient-reported outcomes for use in lower-risk myelodysplastic syndromes. J Patient Rep Outcomes 4, 69 (2020).

Yellen, S.B., Cella, D.F., Webster, K.A., Blendowski, C., & Kaplan, E.  Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) Measurement System.  Journal of Pain and Symptom Management 1997; 13(2): 63-74.  

Bonomi, A.E., Cella, D.D., Hahn, E.A., Bjordal, K., Sperner, B., Gangeri, L., Bergman, B., Willems, J., Hanquet, P., & Zittoun, R.  Multilingual translation of the Functional Assessment of Cancer Therapy (FACT) quality of life measurement system.  Quality of Life Research 1996; 5: 309-320.

Eremenco, S., Arnold, B., Cella, D. A comprehensive method for the translation and cross-cultural validation of health status questionnaires. Evaluation & the Health Professions 2005; 28(2): 212-232.

Webster K., Cella D., Yost K. The Functional Assessment of Chronic Illness Therapy (FACIT) measurement system: Properties applications, and interpretation. Health and Quality of Life Outcomes 2003; 1(1): 79-85.

Yost K.J., Eton D.T. Combining distribution- and anchor-based approaches to determine minimally important differences: The FACIT experience. Evaluation & the Health Professions 2005; 28(2): 172-191.

Related Measures

Related Measures


Functional Assessment of Chronic Illness Therapy – Fatigue Scale


Functional Assessment of Chronic Illness Therapy – Fatigue

PROMIS SF v1.0 – Fatigue 13a

Patient-Reported Outcomes Measurement Information System Short Form - Fatigue 13a

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